The effect of cigarette smoke on the plasma piroxicam concentrations in rats
Makaleler > Tam Makale · 1990
Yazarlar: Ferzan Lermioǧlu, Tayfun Berkan, Mukadder Yasa, Zeliha Kerry, Cengiz Yalçinkaya, Asli özer
Journal of Pharmacy and Pharmacology, Uluslararası, 1990, cilt 42, ss 802-803
DOI: 10.1111/j.2042-7158.1990.tb07026.x
Özet
The plasma concentration of unchanged piroxicam has been determined at 15, 30, 60 and 90 min after 10 mg kg-1 oral administration of the drug to rats exposed to cigarette smoke or pretreated with phenobarbitone, 3,4-benzpyrene or ethanol. Plasma piroxicam concentrations decreased in rats pretreated with phenobarbitone, 3,4-benzpyrene and ethanol and in rats 24 h after exposure to cigarette smoke.