Komplike Olmayan Üriner Sistem Enfeksiyonlarında Lokal Antibiyotik Direncinin Çok Merkezli Taranması: 37 Merkezden 1850 Hasta
Makaleler > Tam Makale · 2024
Yazarlar: Ahmet Emre Cinislioğlu, Nazan Cinislioğlu, Metin İshak Öztürk, Fatih Akkaş, Tugay Aksakallı, Mustafa Kemal Atilla, Gökhan Atış, Hasan Rıza Aydın, Uğur Balcı, Ömer Bayrak, Selahattin Bedir, Hüseyin Biçer, Gökhan Çevik, Ali Çift, Halil Çiftçi, Burhan Coşkun, Şaban Oğuz Demirdöğen, Mehmet Kutlu Demirkol, Murat Dinçer, Ahmet Emin Doğan, Murat Dursun, Fikret Erdemir, Anıl Erkan, Bilal Eryıldırım, Sadık Görür, Fatih Hızlı, Mustafa Kadıhasanoğlu, Senad Kalkan, İbrahim Karabulut, Mehmet Zeynel Keskin, Fuat KIZILAY, Osman Köse, Eyüp Veli Küçük, Öner Odabaş, Taylan Oksay, İsa Özbey, Ertuğrul Şefik, Mehmet Giray Sönmez, Mesut Tek, Devrim Tuğlu, Ömer Levent Tuncay, Mustafa Faruk Usta, Sercan Yılmaz, Ateş Kadıoğlu
Mikrobiyoloji Bulteni, Uluslararası, Scopus, 2024, cilt 58, ss 366-379
DOI: 10.5578/mb.20249658
Özet
This study was aimed to identify the most frequently observed pathogens in uncomplicated urinary tract infections from outpatient urinary isolates obtained across seven different geographical regions in Türkiye and to determine whether the antibiotic resistance rates of these pathogens differ significantly between these regions. The study included patients aged 18 to 65 years who were diagnosed with uncomplicated urinary tract infections and had positive urine cultures from March 2021 to August 2022, across 37 different centers in Türkiye. The participating centers were selected based on their use of the disk diffusion method, in line with the European Committee on Antimicrobial Susceptibility Testing (EUCAST) guidelines, to ensure standardization of urine culture data. A total of 1850 patients who met the inclusion criteria were included in the study. The analysis of the distribution of antibiotic resistance rates in Escherichia coli isolates revealed statistically significant differences in resistance to ampicillin, fosfomycin and nitrofurantoin across different regions (p< 0.05, p< 0.05, p< 0.05, respectively). The Southeastern Anatolia region was identified as having the highest resistance rates to fosfomycin and trimethoprim-sulfamethoxazole (27.4% and 35.3%, respectively). Additionally, the region with the highest nitrofurantoin resistance was determined as the Eastern Anatolia Region with a rate of 35.7% and the region with the highest ciprofloxacin resistance was determined as the Central Anatolia Region with a rate of 51%. Our study demonstrated that antibiotic resistance in the treatment of uncomplicated urinary tract infections varies by geographical region. We believe this comprehensive, national prospective study will provide valuable insights for clinicians planning empirical treatment for uncomplicated urinary tract infections.