A new cycloartane-type glycoside from Astragalus schottianus Boiss.
Makaleler > Tam Makale · 2009
Yazarlar: F Karabey, E Bedir
Planta Medica, Uluslararası, Wos, 2009, cilt 75
Özet
Astragalus L., the largest genus in the family Leguminosae, is represented by 380 species in the flora of Turkey [1]. The roots of Astragalus species represent a very old and well-known drug in traditional medicine for its usage as an antiperspirant, diuretic and tonic drug [2]. In the district of Anatolia, located in South Eastern Turkey, an aqueous extract of the roots of Astragalus is traditionally used against leukemia and for its wound-healing properties. Known biologically active constituents of Astragalus roots represent two major classes of chemical compounds, polysaccharides and saponins [2]. In our continuing search on Turkish Astragalus species, we have isolated a new cycloartane-type triterpene glycoside from methanolic extract of A. schottianus together with three known compounds by combined chromatografies on reverse phase C-18 and silica gel. The structure of the new compound ( 1 ) was determined as 20(R),25-epoxy-3- O -[α-L-arabinopyranosyl(1→2)-β-D-xylopyranosyl]-24- O -β-D-glucopyranosyl-3β,6α,16β,24α-tetrahydroxy-cycloartane by a combination of one- and two-dimensional NMR techniques. References: [1] Davis, P.H. (1978) „ Flora of Turkey and East Aegean Islands“ Vol.3, University Press: Edinburgh. [2] Tang, W., Eisenbrand, G. (1992), „ Chinese Drugs of Plant Origin“ Springer-Verlag, Berlin.