Analysis of matrix metalloproteinases, especially MMP-8, in gingival creviclular fluid, mouthrinse and saliva for monitoring periodontal diseases
Articles > Article · 2015
Authors: Timo Sorsa, Ulvi K. GURSOY, Solomon NWHATOR, Marcela HERNANDEZ, Taina Tervahartiala, Jussi LEPPILAHTI, Mervi GURSOY, Eija KONONEN, Gülnur EMİNGİL, Pirkko J. PUSSINEN, Paivi MANTYLA
PERIODONTOLOGY 2000, Journal Indexed in SCI Expanded, International, 2015, vol 70, pp 142-163
DOI: 10.1111/prd.12101
Summary
Matrix metalloproteinase-8 is a promising candidate biomarker for oral fluid (gingival crevicular fluid, peri-implant sulcular fluid and saliva) and mouthrinse chair-side/point-of-care diagnostics to predict, diagnose and determine the progressive phases of episodic periodontitis and peri-implantitis, as well as to monitor the treatments and medications. Matrix metalloproteinase-8 can be used alone or together with interleukin-1beta and Porphyromonas gingivalis to calculate cumulative risk score at the subject level as a successful diagnostic tool, especially in large-scale public health surveys, in which a thorough periodontal examination is not feasible.