Boric Acid Treatment Strengthens the Cytotoxic Effect of Sorafenib on Triple Negative Breast Cancer Cell Lines
Makaleler > Tam Makale · 2023
Yazarlar: Erkan KAHRAMAN, Erdem GÖKER
Celal Bayar Üniversitesi Fen Bilimleri Dergisi, Hakemli Üniversite Dergisi, Uluslararası, Ebscohost, 2023, cilt 19, ss 137-141
DOI: 10.18466/cbayarfbe.1201068
Özet
In recent years, it has been demonstrated that combinational therapies have shown promising results in the treatment of triple negative breast cancer. However, the effect of the sequential combination of sorafenib with boric acid on cell viability in triple negative breast cancer cell lines is unknown. Thus, the present study aims to investigate the effects of sequential treatment of boric acid and sorafenib on cell viability in triple negative breast cancer cell lines. MDA-MB-231 cells were used in our study. Sorafenib was treated to the cells at a dose range of 0.5-16µM, and boric acid at 1-160mM. Changes in cell viability were determined using by MTT analysis at 24,48 and 72 hours. Cell viability decreased statistically significantly at 4µM and above doses of sorafenib, and 5mM and above doses of boric acid (p