The expression of astroglial glutamate transporters in patients with focal cortical dysplasia: an immunohistochemical study
Articles > Article · 2009
Authors: Mustafa Onur Ulu, Taner Tanriverdi, Buge Oz, Hüseyin BİÇEROĞLU, Cihan Isler, Berna Senel Eraslan, Cigdem Ozkara, Emin Ozyurt, Mustafa Uzan
ACTA NEUROCHIRURGICA, Journal Indexed in SCI Expanded, International, 2009, vol 152, pp 845-853
DOI: 10.1007/s00701-009-0548-2
Summary
An abnormal increase in the extracellular glutamate is thought to play a crucial role in the initiation, spread, and maintenance of seizure activity.In normal conditions, the majority of this excess glutamate is cleared via glial glutamate transporters (EAAT-1 and EAAT-2). We aimed to examine the immunohistochemical expression of these transporters in the dysplastic tissues of patients with focal cortical dysplasia (FCD).