Cyclosporine A-Loaded Solid Lipid Nanoparticles: Ocular Tolerance andIn VivoDrug Release in Rabbit Eyes
Articles > Article · 2009
Authors: Evren Homan GÖKÇE, Giuseppina SANDRİ, SAİT EĞRİLMEZ, M. Cristina Bonferoni, Tamer GUNERI, Carla CARAMELLA
Current Eye Research, Journal Indexed in SCI Expanded, International, WoS, 2009, vol 34, pp 996-1003
DOI: 10.3109/02713680903261405
Summary
PURPOSE: To determine the in vivo efficacy of cyclosporine A-loaded solid lipid nanoparticles (SLNs) in rabbit eyes. METHODS: SLNs were prepared and administered to the cul-de-sac of rabbits, and the drug amount in aqueous humor was detected by high performance liquid chromatography (HPLC). The irritation was evaluated by modified Draize testing. RESULTS: The particle size of SLNs was detected as 225.9 +/- 5.5 nm with a negative surface charge. Aqueous humor drug levels reached 50.53 ng/mL, and there was no serious irritation in rabbit eyes. CONCLUSIONS: Topical ophthalmic efficacy of cyclosporine A was enhanced via administration of SLNs.