Radiosynthesis and biodistribution of Tc-99m-Sulfamethoxazole: a novel molecule for in-vivo infection imaging
Makaleler > Tam Makale · 2017
Yazarlar: Ozge Uyaroglu, Hasan Demiroglu, Gokcen Topal, Yasemin Parlak, Fikriye Gul Gumuser, Elgin Uluer Turkoz, Volkan Demir, Buket Ates, Perihan ÜNAK, Ugur Avcibasi
MEDICINAL CHEMISTRY RESEARCH, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2017, cilt 26, ss 3149-3157
DOI: 10.1007/s00044-017-2009-4
Özet
The aim of this study was to prepare Tc-99m-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with Tc-99m and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 +/- 3.07% and remained constant at more than 93 +/- 0.1% even in serum for 240 min after radiolabeling. Tc-99m-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. Tc-99m-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging.