Carotid intima‐media thickness in chronic obstructive pulmonary disease and survival: A multicenter prospective study
Makaleler > Tam Makale · 2019
Yazarlar: Gazi Gulbas, Onur Turan, Nurhan Sarioglu, Ozlem Ercen Diken, Nalan Ogan, Esra Ekbic Kadioglu, Ercan Kurtipek, Fulsen Bozkus, Nilgün Yilmaz Demirci, Ayşe Coskun Beyan, Levent Cem Mutlu, Sezgi Sahin Duyar, Sami Deniz, Nevin Fazlioglu, Aysun Sengul, Hakan Tanriverdi, Oğuzhan Okutan, Pakize Ayse Turan, Handan İnonu, Mediha Gonenc Ortakoylu, Huseyin Lakadamyali, Tulay Kivanc, Ozgur Atli̇, Ozer Özdemir, A. Filiz Koşar, Arzu Mirici, Mecit Suerdem
The Clinical Respiratory Journal, Uluslararası, Wos, 2019, cilt 13, ss 391-399
DOI: 10.1111/crj.13024
Özet
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is associated with increased cardiovascular morbidity and mortality. Carotid intima-media thickness (CIMT) is a noninvasive method assessing atherosclerosis. OBJECTIVE: It was aimed to determine relationship and survival between COPD and CIMT. METHODS: CIMT was measured using Doppler ultrasound (USG) in 668 stable COPD patients at 24 centers. Patients were followed-up for 2 years. RESULTS: (P < 0.05). According to logistic regression model, compared with group A, risk of CIMT increase was 2.2-fold in group B, 9.7-fold in group C and 4.4-fold in group D (P < 0.05). Risk of CIMT increase was also related with cholesterol level (P < 0.05). Compared with infrequent exacerbation, it was 2.8-fold in the patients with frequent exacerbation (P < 0.05). The mean survival time was slightly higher in group 1, but not significant (23.9 vs 21.8 months) (P > 0.05). CONCLUSION: This study is the first regarding CIMT with combined GOLD assessment groups. It has revealed important findings supporting the increase in atherosclerosis risk in COPD patients. We recommend Doppler USG of the carotid artery in COPD patients at severe stages.