Efficacy and safety of ruxolitinib in regularly transfused patients with thalassemia: results from a phase 2a study
Makaleler > Tam Makale · 2017
Yazarlar: Ali T. Taher, Zeynep Karakas, Elena Cassinerio, Noppadol Siritanaratkul, Antonis Kattamis, Aurelio Maggio, Stefano Rivella, Norbert Hollaender, Bruyère Mahuzier, Brian Gadbaw, Yeşim AYDINOK
Blood, Uluslararası, Wos, 2017, cilt 131, ss 263-265
DOI: 10.1182/blood-2017-06-790121
Özet
Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm derived from non-Langerhans histiocytic cells of the monocyte/macrophage system that is diagnosed using immunohistochemistry markers, such as CD68, lysozyme, CD4, and CD163, on the tissue biopsies.1 HS can occur in isolation or in association with other hematological neoplasms like non-Hodgkin lymphoma (NHL), myelodysplasia, or acute leukemia.2 HS has variable clinical presentation and outcomes, ranging from localized disease to multiple sites within a single system, to life-threatening disseminated disease (preferentially involving the skin, soft tissue, and gastrointestinal tract).