Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients
Makaleler > Tam Makale · 1998
Yazarlar: B SOZMEN, C KAZAZ, Dilek TAŞKIRAN, S TUZUN, Eser YILDIRIM SÖZMEN
CURRENT MEDICAL RESEARCH AND OPINION, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 1998, cilt 14, ss 89-96
DOI: 10.1185/03007999809113347
Özet
Defective endothelium-dependent vascular relaxation has been found in animal models of hypertension and in hypertensive patients. An inbalance due to reduced production of nitric oxide (NO) or increased production of free radicals, mainly the superoxide anion, may facilitate the development of an arterial functional spasm. Although it has been shown that many antihypertensive drugs can normalise both tire antioxidant activity and NO, the antioxidant effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341), an alpha-adrenoreceptor agonist, has not been investigated. In this study the investigated tire antioxidant and NO status in hypertensive patients and whether there was any effect of S-3341 or? these parameters.