Obstructive sleep apnea is an independent predictor for dyslipidemia: Data from the European Sleep Apnea Database (ESADA)
Bildiriler > Özet Bildiri · 2017
Yazarlar: Canan GÜNDÜZ, Özen KAÇMAZ BAŞOĞLU, Jan HEDNER, Ding ZOU, Maria R. Bonsignore, Holger HEIN, Richard STAATS, Athanasia PATAKA, Ferran BARBE, Pavel Sliwinsky, Ludger GROTE
Sleep and Control of Breathing, İtalya, Uluslararası, Sözlü Sunum, Özet Bildiri, 2017-2017, Wos, cilt 50, ss OA3208-OA3208
DOI: 10.1183/1393003.congress-2017.oa3208
Özet
Background and aim: Obstructive sleep apnea (OSA) and dyslipidemia are both independently well-recognized risk factors for cardiovascular disease. Previous data are inconclusive regarding the relationship between OSA and dyslipidemia. The aim of the present study was to investigate the association between OSA and dyslipidemia in ESADA (European Sleep Apnea Database). Methods: The cross-sectional analysis included 8592 patients (age 50.1±12.7 years, 69.1% male, BMI 30.8±6.6 kg/m2, mean AHI 25.7±25.9 n/h) from the ESADA. The independent relationship between measures of OSA (AHI, ODI, mean and lowest saturation) and lipid profile (total cholesterol [TC], HDL-cholesterol [HDL-C] (n=3289) and fasting triglyceride [TG] (n=4612)) was determined by means of General Linear Model analysis. Patients with known hyperlipidemia and/or lipid-lowering medication were excluded. Results: TC had a strong linear association with ODI (mean±SE [mg/dl] 180.33±2.46, 184.59±2.42, 185.44±2.42 and 185.73±2.44; p<0.001 for ODI quartiles I-IV). Comparable results were seen for AHI, mean and lowest saturation. TG were slightly better predicted by AHI than by ODI. HDL-C was significantly reduced in the highest quartile of AHI (mean±SE [mg/dl] 48.8±1.49 vs. 46.50±1.48; p=0.002, quartile I vs. IV). Morbid obesity was associated with lower TC and higher HDL-C values. European regions influenced lipid status, patients from the North had highest and from the West had lowest TC values (mean±SE [mg/dl] 192.55±2.27 versus 177.80±2.75, p<0.001). Conclusion: OSA has an independent association with dyslipidemia, but the effect size is limited.