Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats.
Makaleler > Tam Makale · 2004
Yazarlar: Zeki Eralp BUDUNELİ, S VARDAR, Nurcan Gülsüm BUDUNELİ, Afig BERDELİ, O TURKOGLU, A BASKESEN, FATMA GÜL ATİLLA
JOURNAL OF PERIODONTOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 75, ss 1516-1523
DOI: 10.1902/jop.2004.75.11.1516
Özet
Background: Doxycycline has been widely used in periodontal treatment for its antimicrobial and anti-enzymatic effects. Recently, bisphosphonates have been shown to inhibit alveolar bone resorption. The aim of the present study was to evaluate the effects of doxycycline and the bisphosphonate alendronate on the gingival tissue levels of prostaglandin E-2 (PGE(2)), prostaglandin F-2alpha (PGF(2alpha)), leukotriene B-4 (LTB4), and platelet-activating factor (PAF) in endotoxin -induced periodontal breakdown in rats.