DERMATOLOGICAL DRUG DEVELOPMENT STRATEGIES AND SELECTION OF A TOPICAL CANDIDATE DRUG
Book chapter > Chapter Research Book · 2020
Authors: Evren Homan GÖKÇE, Zennure Takcı
Dermatology, Chapter Research Book, Türkiye Klinikleri Yayınevi, Nationally Recognized, National, 2020, pp 30-36, Turkey, Ankara
Summary
<p>Topical application of drugs to the skin dates back thousands of years. Thanks to its unique semi-permeable barrier property, the skin prevents the penetration of chemicals from the external environment and microorganisms.</p><p>It protects the body against the transepidermal loss of endogenous fluid substances such as water while preventing invasion. The most important feature limiting the passage of active substances in topical formulations for local (dermal) or systemic (transdermal) effect is the unique barrier structure of the skin.</p><p>In this article, topical candidate drug selection and dermatological drug development strategies were discussed considering the structural and functional properties of the skin.</p>