The associations between serum paraoxonase 1 activity and carotid atherosclerosis in renal transplant patients
Makaleler > Tam Makale · 2013
Yazarlar: Ozkan GUNGOR, ERKAN KISMALI, Ali Riza Sisman, Fatih KIRCELLI, Gülay AŞCI, Kenan Topal, Savas SİPAHİ, Pinar TUNCEL, Mehmet ÖZKAHYA, Hüseyin TÖZ
CLINICAL NEPHROLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2013, cilt 80, ss 198-202
DOI: 10.5414/cn107855
Özet
Backgrounds and aims: Paraoxonase 1 (PON1) is a novel marker that has been shown to exert protective functions on atherosclerosis by preventing oxidative modification of serum lipoproteins. In this study, we investigated the effects of PON1 on CA-IMT in renal transplant patients. Methods: A total of 98 adult renal transplant recipients was enrolled in the study. CA-IMT was determined by B-mode Doppler ultrasonography. PON1 activity was assessed by the rate of enzymatic hydrolysis of paraoxon to p-nitrophenol. Results: Mean age was 39.4 +/- 9.6 years and 10% of the patients were diabetic. Time after transplant was 76 +/- 59 months. Mean PON1 level was 62.1 +/- 43.3 U/l. PON1 levels were negatively correlated with CA-IMT and positively with HDL-cholesterol. Mean CA-IMT was 0.62 +/- 0.10 mm (0.40 - 0.98). CA-IMT was positively correlated with age, male gender and negatively with proteinuria and PON1 levels. In linear regression analysis, PON1 levels were associated with CA-IMT. Conclusion: Reduced PON1 activity is significantly associated with increased carotid atherosclerosis in renal transplant patients.