Retrospective analysis of hysteroscopic findings in breast cancer patients having adjuvant tamoxifen treatment
Articles > Article · 2010
Authors: Fatih ŞENDAĞ, Çağdaş ŞAHİN, B. Zeybek, Mustafa Coşan TEREK, K. Oztekin, O. Bilgin
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, Journal Indexed in SCI Expanded, International, 2010, vol 31, pp 415-417
Summary
Purpose of Investigation: To evaluate the effects of tamoxifen on the endometrium of breast cancer patients by hysteroscopy and endometrial sampling. Methods: Thirty-seven breast cancer patients using tamoxifen underwent hysteroscopy because of postmenopausal endometrial thickening or abnormal uterine bleeding. Hysteroscopic findings were compared with histopathology and ultrasonographic measurement of the endometrium. Results: Nineteen women showed endometrial abnormalities (51%) out of 37 patients. Negative and positive predictive values for hysteroscopy in detecting endometrial abnormalities were 100% and 94%, respectively. Conclusion: Endometrial surveillance is an important part of gynecological follow-up in breast cancer patients using tamoxifen and the liberal use of hysteroscopy aids in the diagnosis of abnormal endometrium.