Preliminary Studies on a New Group of Imidazole Derivatives with Anticonvulsant Activity : Antikonvülzan Aktivite Gösteren İmidazol Türevi Yeni Bir Grup Madde ile Yapılan Ön Çalışmalar
Makaleler > Tam Makale · 1989
Yazarlar: Levent ÜSTÜNES, Mehmet Varol PABUÇÇUOĞLU, Tayfun BERKAN, Aslı ÖZER
Ankara Universitesi Eczacilik Fakultesi Dergisi, Uluslararası, 1989, ss 039-045
DOI: 10.1501/eczfak_0000000301
Özet
In a preliminary study, the anticonvulsant profiles of three compounds having the basic structures w-(l H-l-imidazolyl)-N-(p-substituted phenyl) acetamide, propionamide and butiramide with methyl substituents on the para position of benzene ring have been evaluated in mice in comparison with the standart antiepileptic drug, phenobarbital. The anticonvulsant activities of these compounds against maximal electroshock induced seizures were comparable to or less than that of phenobarbital. Further studies on the anticonvulsant activities and the toxicological characteristics of these compounds are now in progress in our department.