A Novel DAD Type and Folic Acid Conjugated Fluorescent Monomer as a Targeting Probe for Imaging of Folate Receptor Overexpressed Cells
Makaleler > Tam Makale · 2014
Yazarlar: Fulya Ekiz Kanik, Didem AG, Muharrem ŞELECİ, Firat Baris BARLAS, Melis Kesik, Gonul Hizalan, Hava Akpinar, Suna TİMUR, Levent Toppare
BIOTECHNOLOGY PROGRESS, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2014, cilt 30, ss 952-959
DOI: 10.1002/btpr.1928
Özet
We describe a modification and post-functionalization technique for a donor-acceptor-donor type monomer; 6-(4,7-bis(2,3-dihydrothieno[3,4-b][1,4]dioxin-5-yl)-2H-benzo[d][1,2,3]triazol-2-yl)hexan-1-amine. Folic acid was attached to the fluorescent structure. The conjugation was confirmed via NMR and Fourier transform infrared analyses. Cytotoxicity was investigated and the comparison of association of targeted monomeric structures in tumor cells was monitored via fluorescence microscopy. (C) 2014 American Institute of Chemical Engineers