ENCAPSULATION OF INSULIN IN CHITOSAN-COATED ALGINATE BEADS: ORAL THERAPEUTIC PEPTIDE DELIVERY
Articles > Article · 2002
Authors: Seçil ÖNAL, Figen ZİHNİOĞLU
Artificial Cells, Blood Substitutes, and Biotechnology, Journal Indexed in SCI Expanded, International, WoS, 2002, vol 30, pp 229-237
Summary
Insulin was encapsulated in calcium alginate beads coated with chitosan. Its release from alginate-chitosan and alginate-chitosan-glutaraldehyde beads was studied in artificial gastric (pH 1.2) and intestinal (pH 7.5) fluids. By comparing the release amounts, the ionic interaction between alginate-chitosan matrix with the medium pH's, intestinal fluid was found to be the better. The degradation of released insulin was also searched, even after 6 h incubation, the beads remained stable and the undegraded insulin seemed to be sufficient for the physiological conditions. Consequently, it can be said that the system can be offered for oral delivery of the therapeutic peptide drug insulin.