Evaluation of Long Term Respiratory Complications in Childhood and Adolescent Cancer Survivors
Makaleler > Tam Makale · 2023
Yazarlar: Fırat ERGİN, Nazan Çetingül, Esen Demir, Abdullah SAYINER, Hüdaver Alper, Figen GÜLEN
The Journal of Pediatric Research, Uluslararası, Scopus, 2023, cilt 10, ss 13-18
DOI: 10.4274/jpr.galenos.2022.98216
Özet
IntroductionChildhood and adolescent cancers are an increasing health problem and constitute 1-2% of all lifelong cancers.According to US data, the incidence of cancer in children and adolescents was 14.2/100,000/year in 1975, and this increased to 17.4/100,000/year in 2009.Correspondingly, there was a notable reduction in mortality in these patients (from 5.2/100,000 to 2.4/100,000) (1).More than 1% of the young adult population are survivors of childhood cancer (2).Two-thirds of longterm survivors had at least one health problem in the late period.According to the results of the Childhood Cancer Survivors Study, for at least 5 years after cancer diagnosis, ABS TRACT Aim: In addition to increased survival rates, systemic complications which can impair the quality of life have been seen in 25-30% of childhood and adolescent cancer cases.The respiratory system is one of the severely affected systems.We aimed to evaluate late respiratory complications and risk factors in pediatric and adolescent cancers. Materials and Methods:We examined the pulmonary complications of 50 cancer patients and 40 control cases.We asked about environmental exposures, physical examinations performed, and pulmonary function tests (PFT) spirometry, diffusing capacity of the lungs for carbon).X-ray was performed on all patients in the patient group and on patients with indications in the control group.Results: In the patient group, there was impairment of pulmonary function in 52%, [24% small airway disease (SAD)], 14% diffusion disorders (DD) and 14% combined disorders (CD) compared to 22.5% in the control group (p=0.007).There was a higher risk of restrictive disorder and/ or SAD in those cancer patients who were diagnosed prior to 2 years of age.Additionally, there was a higher rate of SAD in those patients with soft tissue sarcomas and a higher rate of restrictive disease in those patients who had received high-dose alkylating agents.No significant PFT impairment was observed in the other patient groups.Conclusion: There is a high incidence of respiratory impairment in childhood and adolescent cancer survivors.They need to be followed up by a multidisciplinary team and be informed about the additional risk factors which may cause lung function loss.