Clinical significance of ASCUS and ASC-H cytological abnormalities: a six-year experience at a single center
Articles > Article · 2015
Authors: G. S. DEMIRTAS, Levent AKMAN, O. DEMIRTAS, B. S. Hursitoglu, Mustafa Coşan TEREK, O. Zekioglu, H. Yilmaz, A. A. Ozsaran
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, Journal Indexed in SCI Expanded, International, 2015, vol 36, pp 150-154
Summary
Background: To evaluate colposcopic biopsy results of patients with cervical cytological findings of atypical squamous cells of undetermined significance (ASC-US) and atypical squamous cells with high-grade lesions that cannot be excluded (ASC-H). Materials and Methods: A retrospective evaluation of data from 358 patients, who had cervical cytological findings of ASC-US (n=335) and ASC-H (n=23), and had colposcopic assessments between 2005 and 2011. Results: Cervical biopsy results of patients diagnosed with ASC-US cytology (n=335) revealed cervical squamous cell carcinoma 0.9 % (n=3) at biopsy, cervical intraepithelial neoplasia 3 (ON 3) in 3.8 % (n=13), cervical intraepithelial neoplasia 2 (CIN 2) in 1.1 % (n=4), cervical intraepithelial neoplasia 1 (CIN 1) in 35.2 % (n=118), and benign lesions in 59% (n=197). Cervical biopsy results of patients diagnosed with ASC-H cytology (n=23) revealed CIN 3 at biopsy in 39.3% (n=9), CIN 2 in 21.7% (n=5), CIN 1 in 26% (n=6), carcinoma in situ in 8.7% (n=2), and squamous cell cancer in one patient (4.3%). Conclusion: The cytological diagnosis of ASC-US may lead to the diagnosis of cervical intraepithelial lesion of higher grades as well as cervical cancer and should be evaluated by colposcopic cervical biopsy.