Evaluation of lipid peroxidation and total antioxidant capacity in patients with uterine cancer
Diğer yayınlar > Diğer · 2022
Yazarlar: behrouz shademan, Soltan Ali Mahboob, Ghodsie Ravanbakhsh, Alireza Nourazarian
Diğer, Uluslararası, 2022,
Özet
Abstract Oxidative stress has been associated with developing many female reproductive diseases, including uterine cancer. This study investigated lipid peroxidation levels and antioxidant enzyme activity in women with uterine cancer. Blood samples were collected from 50 patients with uterine cancer and 50 healthy subjects as a control group. All subjects gave their informed consent. The blood samples were measured for superoxide dismutase, catalase, glutathione peroxidase, total antioxidants, malondialdehyde, and lipid profiles. Hemoglobin levels of the control group and patients were also measured. Serum levels of TG, LDL, and cholesterol were higher in the patients than in the healthy group but not statistically significant (p > 0.05). Serum HDL levels were lower in the patient group than in the healthy group. However, this decrease was not statistically significant (p > 0.05). The mean levels of glutathione peroxidase (GPx), catalase (CAT), and total antioxidant capacity (TAC) were increased in the patient group compared to the control group, but this increase was not statistically significant (p > 0.05). The mean serum levels of malondialdehyde (MDA) and SOD were increased in the patient group, which was statistically significant (p < 0.05). In addition, the hemoglobin level of patients with uterine cancer was decreased compared to the control group, which was statistically significant (p < 0.05). To develop treatment strategies for disease management. Increased serum levels of MDA and SOD and decreased hemoglobin in the blood of patients with uterine cancer can be considered diagnostic biomarkers. However, further studies are needed to confirm these findings.