The Knoevenagel-Doebner Reaction on 1,2-O-(2,2,2-Trichloroethylidene) Derivatives of D-Gluco- and D-Manno-furanose
Articles > Article · 2010
Authors: Gökhan KÖK, Tamer KARAYILDIRIM, Kadir Ay, Emriye Ay
MOLECULES, Journal Indexed in SCI Expanded, International, 2010, vol 15, pp 7724-7731
DOI: 10.3390/molecules15117724
Summary
The synthesis of new alpha,beta-unsaturated furanuronic acid derivatives of alpha-gluco-(3), beta-gluco-(6) and beta-manno-chloraloses (9) via a convenient one pot procedure using the Knoevenagel-Doebner reaction approach are described. The dialdofuranose derivatives were reacted with malonic acid under Knoevenagel-Doebner reaction conditions and (E)-alpha,beta-unsaturated furanuronic acid derivatives were obtained.