Cycloartane glycosides from Astragalus aureus
Makaleler > Tam Makale · 2011
Yazarlar: Derya GÜLCEMAL, Özgen ALANKUŞ, Angela PERRONE, Fevzi Özgökçe, Sonia PIACENTE, ERDAL BEDİR
Phytochemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2011, cilt 72, ss 761-768
DOI: 10.1016/j.phytochem.2011.02.006
Özet
Eight cycloartane-type triterpene glycosides (1-8) were isolated from Astragalus aureus Willd along with ten known cycloartane-type glycosides (9-18). Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analyses. Compounds 1-5 are cyclocanthogenin glycosides, whereas compounds 6-8 are based on cyclocephalogenin as aglycon, more unusual in the plant kingdom, so far reported only from Astragalus spp. Moreover, for the first time monoglycosides of cyclocanthogenin (5) and cyclocephalogenin (7, 8) are reported. All of the compounds tested for their cytotoxic activities against a number of cancer cell lines. Among the compounds, only 8 exhibited activity versus human breast cancer (MCF7) at 45 mu M concentration. (C) 2011 Elsevier Ltd. All rights reserved.