Mutagenicity of Nonylphenol and Octylphenol Using <i>Salmonella</i> Mutation Assay
Makaleler > Tam Makale · 2007
Yazarlar: Meltem Boyacioglu, Özlem ÇAKAL ARSLAN, Hatice Parlak, Muhammet Ali Karaaslan
SU URUNLERI DERGISI, ESCI İndekslerine Giren Dergi, Uluslararası, Wos, 2007, cilt 24, ss 299-302
Özet
In this study, mutagenic ability of Nonylphenol (NP) and Octylphenol (OP) were tested considering these chemicals are widely used in industry and in some domestic products and they are found widely in surface water, sea water, ground water and aquatic sediments. Although abundant data are available on the toxicity and estrogenic effects of NP and OP, little is known about the mutagenicity of these chemicals. Six concentrations ranging from 0.937 to 4.685 mu g/L of NP and five concentrations ranging from 10 to 160 mu g/L of OP was tested in the His+ revertant assay with the use of Salmonella thyphimirium TA98 and TA 100 without metabolic activation. All NP concentrations showed non- mutagenic activity although; it had toxic characteristics exhibiting growth rate less than that of the spontaneous revertant colonies. Besides that, mutagenicity was observed at 40 mu g/L for OP tested with TA98 strains and 20 mu g/L for OP tested with TA100 strains of Salmonella thyphimirium. These findings will contribute to assess their environmental impacts showing the mutagenic effects of OP and toxic effects of NP on S. typhirmirum in environmentally relevant concentrations.