The Effects of Garlic Extracts on Prostate Cancer
Makaleler > Tam Makale · 2025
Yazarlar: Furkan Kuznek, Recep İLHAN, Gökçe YILDIRIM BUHARALIOĞLU, Ahmet EMİR
Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Hakemli Üniversite Dergisi, Ulusal, TR Dizin (Ulakbim), 2025, cilt 18, ss 781-788
DOI: 10.18185/erzifbed.1641990
Özet
<p>In the current study, garlic samples obtained from various provinces of Turkey, including Kastamonu, Balikesir, Edirne, and Aksaray, were analyzed for their chemical composition and biological activity. The organosulfur content of the prepared extracts was assessed using GC-MS. A total of seven compounds were identified across all samples, with 3-Vinyl-4H-1,2-dithiin and 2-Vinyl-4H-1,3-dithiin recognised as the predominant compounds. Additionally, the effects of these extracts at concentration of 25, 50, 75, 100, 150 and 200 µg/ml on benign prostatic hyperplasia (BPH), as well as on the LNCaP, DU145, and PC3 cell lines, were evaluated using MTT assays. Cytotoxic activity was detected in all samples examined. The most pronounced activity was recorded against the LNCaP cell lines, exhibiting varying IC50 values ranging from 23.91 to 48.84 µg/ml. </p>