Radiolabeling and in vitro evaluation of Tc-99m-methotrexate on breast cancer cell line
Articles > Article · 2015
Authors: Emre ÖZGENÇ, Meliha EKİNCİ, Derya İLEM ÖZDEMİR, Evren ATLIHAN GÜNDOĞDU, MAKBULE AŞIKOĞLU
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2015, vol 307, pp 627-633
DOI: 10.1007/s10967-015-4210-6
Summary
In the present study Tc-99m-MTX was prepared with high labeling yield by a new simple and easy formulation method. According to cell culture studies, Tc-99m-MTX incorporated with both MCF-7 and CRL8798 cells, with significant differences in the uptake percentages. Since Tc-99m-MTX highly uptake in cancer cell line, the results demonstrated that radiolabeled MTX may be promising for breast cancer diagnosis of oncological patients.