Frailty and Cognitive Function in Middle-Aged and Older Adults With Congenital Heart Disease
Makaleler > Tam Makale · 2024
Yazarlar: Bo Daelman, Liesbet Van Bulck, Koen Luyckx, Adrienne H. Kovacs, Alexander Van De Bruaene, Magalie Ladouceur, Hsiao Ling Yang, Ju Ryoung Moon, André Schmidt, Birgitte Lykkeberg, Edward Callus, Michèle de Hosson, Camilla Sandberg, Bengt Johansson, Joanna Hlebowicz, Maria Emília Areias, Pascal Amedro, Louise Coats, Zacharias Mandalenakis, Anna Kaneva, Philip Moons, Eva Goossens, Navaneetha Sasikumar, Junko Enomoto, Yoshiko Mizuno, Ming Chern Leong, Izzatun Nafsi Binto Sabran, Laila Akbar Ladak, Babar Hasan, Ayat Siddiqui, June Huh, Jou Kou Wang, Chun Wei Lu, Fatma Demir, Tuğba Nur ÖDEN, Endale Tefera, Julius Mwita, Jean Claude Ambassa, Charles Mvondo, Marcel Fanka, Dejuma Yadeta, Mulualem Alemayehu, Mohamed Leye, Khadija Gueye, Harald Gabriel, Matthias Svhneider, Selina Seeliger, Werner Budts, Jessica Rassart, Julie De Backer, Mila Markova, Miriam Biyai, Anissa Boubrit, Jean Benoît Thambo, Amandine Ruissel, Cecile Jore, Hamouda Abassi, Sonia Soltani, Charlene Bredy, George Giannakoulas, Diamantis Kosmidis, Despina Ntiloudi, Silvana Pagliuca, Enrico Giuseppe Bertoldo, Valentina Fiolo, Maryanne Caruana, Justine Swain, Neil Grech, Rachel Xuereb, Sarah Craus, Maria Bonello, Darren Borg, Paul Farrugia, Joanne Cardona, Mette Elise Estensen, Brith Andresen, Katrine Eriksen, Joana Miranda, José Carlos Areias, Cristina Cruz, Filipe Macedo, Filipa Manuela Ribeiro Nunes, Ana Maria Barbosa de Bessa, Sara Mafalda Espírito Santo, Paula Brito, Marisa Pereira, Sofia Teixeira, Brenda Marques, Ana Raquel Marques, Helena Cronesten, Mikael Dellborg, Eva Mattson, Christina Christersson, Louise Robertsson, Linda Ternrud, Corina Thomet, Javier Ruperti, Judith Bouchardy, Fanny Brand
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2024, cilt 83, ss 1149-1159
DOI: 10.1016/j.jacc.2024.01.021
Özet
Background: Life expectancy of patients with congenital heart disease (CHD) has increased rapidly, resulting in a growing and aging population. Recent studies have shown that older people with CHD have higher morbidity, health care use, and mortality. To maintain longevity and quality of life, understanding their evolving medical and psychosocial challenges is essential. Objectives: The authors describe the frailty and cognitive profile of middle-aged and older adults with CHD to identify predictor variables and to explore the relationship with hospital admissions and outpatient visits. Methods: Using a cross-sectional, multicentric design, we included 814 patients aged ≥40 years from 11 countries. Frailty phenotype was determined using the Fried method. Cognitive function was assessed by the Montreal Cognitive Assessment. Results: In this sample, 52.3% of patients were assessed as robust, 41.9% as prefrail, and 5.8% as frail; 38.8% had cognitive dysfunction. Multinomial regression showed that frailty was associated with older age, female sex, higher physiologic class, and comorbidities. Counterintuitively, patients with mild heart defects were more likely than those with complex lesions to be prefrail. Patients from middle-income countries displayed more prefrailty than those from higher-income countries. Logistic regression demonstrated that cognitive dysfunction was related to older age, comorbidities, and lower country-level income. Conclusions: Approximately one-half of included patients were (pre-)frail, and more than one-third experienced cognitive impairment. Frailty and cognitive dysfunction were identified in patients with mild CHD, indicating that these concerns extend beyond severe CHD. Assessing frailty and cognition routinely could offer valuable insights into this aging population.