Ultrastructural features of the bone response to a plasma‐sprayed hydroxyapatite coating in sheep
Makaleler > Tam Makale · 1997
Yazarlar: Joseph Hemmerlé, Aylin Önçag, Selda Ertürk
Journal of Biomedical Materials Research, Uluslararası, Wos, 1997, cilt 36, ss 418-425
DOI: 10.1002/(sici)1097-4636(19970905)36:3<418::aid-jbm17>3.3.co;2-n
Özet
The intentions of this study were to characterize the macrosopic, microscopic, and structural aspects of a plasma-sprayed implant and to thoroughly investigate bone tissue response after its implantation in sheep. Therefore, we used scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, X-ray diffraction, and energy-dispersive X-ray analyses. Assessment of the biomaterial prior to implantation showed a coating with irregular outlines and varying thickness, mainly consisting of hydroxyapatite (HA) covering a rough metallic implant core. Six months after insertion of the HA-coated Ti-6Al-4V implant, neither mechanical failure of the coating-substrate interface nor a significant loss of coating thickness was evident. However, an occasional lack of HA coating and phagocytosis of HA particles were noted. More generally, the implant was surrounded by well-mineralized bone investing the smallest cavities of the plasma-sprayed layer. Newly formed microcrystals with size, shape, and structure similar to those of bone apatite crystals were growing directly at the coating surface. These results suggest that the bone-bonding behavior of the considered grooved implant should provide satisfactory osseointegration and be suitable for fixed prostheses. © 1997 John Wiley & Sons, Inc. J Biomed Mater Res, 36, 418–425, 1997.