LONG-TERM USE OF ANTI-D IN CHRONIC IDIOPATHIC THROMBOCYTOPENIC PURPURA
Articles > Article · 1994
Authors: I YAPRAK, S CAGLAYAN, Savaş KANSOY, E OZDOGRU, AR BAKILER, H AYDINLIOGLU
TURKISH JOURNAL OF PEDIATRICS, Journal Indexed in SCI Expanded, International, 1994, vol 36, pp 43-47
Summary
Chronic idiopathic thrombocytopenic purpura is an autoimmune disease characterized by antibody-mediated destruction of platelets. To maintain the platelets above the symptomatic level, we administered anti-D (100 mu g for 5 consecutive days) in 19 children with idiopathic thrombocytopenic purpura (ITP). Four patients did not respond to treatment. Fifteen responded with an increase in the average platelet number to 76,000 / mu L on the 7(th) postinjection day. Within 45 days, however, platelets dropped to 27,000 / mu L. Three months after this study, two patients from the study group were re-administered anti-D in daily injections for 5 consecutive days, as was done previously. Monthly administration of anti-D in two patients maintained platelets above 30,000 / mu L for periods of five and six months.