Electro-oxidation of cytostatic drugs: Experimental and theoretical identification of by-products and evaluation of ecotoxicological effects
Makaleler > Tam Makale · 2018
Yazarlar: Sibel BARIŞÇI, Ozge Turkay, Ebru Ulusoy, Mine Gül Şeker, Ebubekir Yüksel, Anatoli Dimoglo
CHEMICAL ENGINEERING JOURNAL, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Scopus, 2018, cilt 334, ss 1820-1827
DOI: 10.1016/j.cej.2017.11.105
Özet
Methotrexate (MTX) and Capecitabine (CPC) as mostly used cytostatic drugs were degraded by electro-oxidation process in this study. Ti/IrO2-RuO2 electrode was used to provide anodic oxidation. The effect of change of current density, initial pH of the solution and supporting electrolyte concentration on electro-oxidation of cytostatic drugs was evaluated. Current density of 30 mA/cm2, neutral pH and supporting electrolyte concentration of 200 mg L−1 were determined as optimum operational parameters. After oxidation process, the transformation by-products of cytostatic drugs were identified by LC–MS-MS analysis. Density functional theory (DFT) modelling was performed and the calculations were given in harmony with analytic results. In addition, toxicity evaluation on the electro-oxidation was assessed due to the possible toxic effect of the metabolites after treatment process. Indeed, the transformation by-products of MTX showed toxic effects after treatment, however; the metabolites CPC did not cause toxicity although lower removal efficiency.