The pharmacodynamic effects of rocuronium during general anesthesia in patients with type 2 diabetes mellitus.
Makaleler > Tam Makale · 2010
Yazarlar: I Alper, S Ulukaya, Özer MAKAY, T Balcioglu
Minerva anestesiologica, Uluslararası, 2010, cilt 76, ss 115-9
Özet
AIM: The aim of this prospective study was to investigate whether the neuromuscular response to rocuronium is affected by the presence of type 2 diabetes mellitus. METHODS: Neuromuscular functions were measured after the administration of 0.6 mg/kg rocuronium with train-of-four stimulations in patients with type 2 diabetes mellitus (DM, N=14) and without diabetes mellitus (control, N=14) during isoflurane based general anesthesia. The onset time, clinical duration and recovery index of rocuronium were compared in the two groups. RESULTS: The mean onset time (136 +/- 40 vs 118 +/- 20 s), clinical duration (51 +/- 11 vs 48 +/- 11 min) and recovery index (6.0 +/- 2.5 vs 5.9 +/- 1.4 min) of the neuromuscular block were not significantly different between the DM and control groups, respectively (p>0.05). CONCLUSIONS: The present study has proven that the rocuronium-induced neuromuscular block was not affected in patients with type 2 diabetes mellitus during isoflurane based general anesthesia.