The relationship between the anterior corpus callosum size and prefrontal cortex volume in drug-free depressed patients
Articles > Article · 2013
Authors: Ozgun ÖZALAY, Mehmet Cem ÇALLI, Ömer KİTİŞ, Mehmet Çağdaş EKER, Ozlem Donat Eker, Erol Ozan, Kerry Coburn, Ali Saffet GÖNÜL
JOURNAL OF AFFECTIVE DISORDERS, Journal Indexed in SCI Expanded, International, 2013, vol 146, pp 281-285
DOI: 10.1016/j.jad.2012.06.040
Summary
Introduction: An evolving literature suggests a volume reduction and a loss of functional integrity of prefrontal cortex in depressed patients. Interhemispheric prefrontal functional integrity is mediated via the anterior portion of the corpus callosum. Until recently interhemispheric fibers connecting prefrontal cortex have not been well defined. In this study, we compared the corpus callosum area of depressed patients with controls using a novel schema proposed by Hofer and Frahm (2006) which defined a specific anterior callosal area for prefrontal interhemispheric fibers. We further investigated the correlation between callosal area and prefrontal cortical volume.