Uncatalysed coupling of an activated aryl chloride with aryllithium and aryl Grignard reagents
Makaleler > Tam Makale · 2004
Yazarlar: D Astley, H Saygi, S Gezer, Stephen Thomas ASTLEY
TETRAHEDRON LETTERS, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 45, ss 7315-7317
DOI: 10.1016/j.tetlet.2004.08.003
Özet
Substitution of the chloro group in 2-(2-chlorophenyl)-4,4-dimethyl-2-oxazoline to afford biaryls occurs upon reaction with either aryllithium reagents or aryl Grignard reagents. The reactions with Grignard reagents occur under similar conditions to a previously reported manganese-catalysed procedure. The reactions with lithium reagents, whilst not always affording greater yields of product than the Grignard reagents, involve much shorter reaction times and afford yields, which are comparable with those obtained from the corresponding fluoro derivative. (C) 2004 Elsevier Ltd. All rights reserved.