Radioiodinated Magnetic Nanoparticles Conjugated With Moxifloxacin: Synthesis and In Vitro Biological Affinities
Articles > Article · 2014
Authors: Özge KOZGUŞ GÜLDÜ, Perihan ÜNAK, Emin İlker MEDİNE, F. Baris Barlas, Fazilet Zümrüt BİBER MÜFTÜLER, Suna TİMUR
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, Journal Indexed in SCI Expanded, International, 2014, vol 64, pp 253-259
DOI: 10.1080/00914037.2014.936597
Summary
Magnetic nanoparticles (MNPs) were synthesized and coated with tetraethyl orthosilicate and aminosilane to create functional amino groups. Moxifloxacin (MXF) was conjugated to the modified MNPs using glutaraldehyde as crosslinker. Finally, MXF conjugated magnetic nanoparticles were radiolabeled and their biological affinities such as cell incorporation ratio, cytotoxicity, and their potential as cell imaging probe were investigated using A-549 cells.