Genetic polymorphisms ofinterleukin 1βgene and sporadic pancreatic neuroendocrine tumors susceptibility
Makaleler > Tam Makale · 2016
Yazarlar: Dimitrios Karakaxas, Anna Sioziou, Gerasimos Aravantinos, Ahmet Coker, Ioannis S Papanikolaou, Theodoros Liakakos, Christos Dervenis, Maria Gazouli
World Journal of Gastrointestinal Oncology, Uluslararası, Scopus, 2016, cilt 8, ss 520-520
Özet
AIM: To evaluate the association between the interleukin 1β (IL-1β) polymorphisms and the pancreatic neuroendocrine tumor (pNET) development. METHODS: A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer (51 pNET cases, 85 pancreatic ductal adenocarcinoma cases, 19 intraductal papillary mucinous neoplasm and 98 healthy controls). RESULTS: The distribution of genotypes for the -511 C/T polymorphism in the pNET patient groups showed significant difference compared to the control group. It is known that the carriers of the IL-1β -511T allele have increased concentrations of IL-1β. The -511 CT and TT high-expression genotypes were over-represented in pNET patients. CONCLUSION: The findings of this study suggested a possible role of IL-1β -511 C/T genotypes in the pathogenesis of pNETs since the presence of the IL-1β -511 CT and TT genotypes and the T allele was associated with an increased risk of pNET only.