Long-Term Oncological Outcomes for Locally Advanced Rectal Cancer Patients with Pathological Complete Response After Neoadjuvant Chemoradiotherapy: A Turkish Oncology Group Study
Makaleler > Tam Makale · 2025
Yazarlar: Mukremin Uysal, Sezer Saglam, İsmail Beypınar, Esra Kaytan Saglam, Elkhan Mammadov, Birol Ocak, Ozge Aybi, Rukiye Arıkan, Sefika Arzu Ergen, Pınar GÜRSOY, Abdullah Sakin, Vildan Kaya, Ercan Ozden, Tulay Eren, Atike Gokcen Demiray, Abdilkerim Oyman, Ali Murat Tatli, Haci Mehmet Turk, Ahmet Gulmez, Atakan Demir, Özkan Alan, Teoman Sakalar, Erdem Sen, Gokhan Ucar, Saadettin Kilickap, Ahmet Bilici, Didem Colpan Oksuz, Bulent Karabulut
Cancer Investigation, Uluslararası, Wos, 2025, cilt 44, ss 127-135
DOI: 10.1080/07357907.2025.2595536
Özet
The goal of this study was to look at the long-term survival outcomes and clinical characteristics of stage II/III locally advanced rectal cancer (LARC) patients who acquired pathological complete response (pCR) following neoadjuvant chemoradiotherapy (NCRT). The clinicopathological characteristics and treatment details of 277 LARC patients with pCR, relapse-free survival (RFS), overall survival (OS), and locoregional and systemic recurrence rates, were assessed. The 5-year RFS and OS rates were 85.6% and 90.9%. The rates of local and systemic recurrence were 3.6% and 7.9%. Our study confirmed the favorable results in survival in patients with LARC who achieved pCR.