Constrictive Aspergillosis Pericarditis
Kitapta bölümler > Diğer · 2019
Yazarlar: Neslihan KARACA
Pediatric Immunology, A case-based collection with MCQs, vol II, Diğer, Springer, London/Berlin , A, Uluslararası, 2019, ss 333-339, İsviçre
Özet
<p>A 3-month-old girl was referred to our hospital with a suspicion of Langerhans cell</p><p>histiocytosis. She was hospitalized for pneumonia at the 15th day of birth followed</p><p>by recurrent and treatment resistant cervical lymphadenopathies with high CRP levels.</p><p>She was the first child of a consanguineous family. She had bilateral cervical</p><p>lymphadenopathies and maculopapular skin eruptions over body and legs on admission.</p><p>Laboratory investigations revealed anemia, leukocytosis, high CRP level</p><p>(12 mg/dL), and hypergammaglobulinemia. Histological findings of the skin biopsy</p><p>and lymph node excision were reported as granulomatous inflammation and necrotizing</p><p>granulomatous lymphadenitis, respectively. Meanwhile, oxidative burst</p><p>activity (“Phagoburst” kit, Glycotope, Biotechnology) was insufficient leading to a</p><p>probable diagnosis of chronic granulomatous disease (CGD) later confirmed with</p><p>mutation analysis disclosing a “homozygous autosomal recessive c.369+1G>A</p><p>mutation” in CYBA gene - p22phox. Flow cytometry is currently the method used to</p><p>validate the oxidative capacity of neutrophils</p>