Spermatogenez, spermiyogenezis ve klinik yansımaları
Makaleler > Tam Makale · 2019
Yazarlar: Fuat KIZILAY, Ahmet Barış ALTAY
Androloji Bülteni, Diğer Kurumların Hakemli Dergileri, Uluslararası, TR Dizin (Ulakbim), 2019, cilt 21, ss 177-184
DOI: 10.24898/tandro.2019.27443
Özet
İnfertilite, çiftlerin %15-20 kadarında görülmektedir.[1] Vakaların yarısından fazlasında, erkekle ilgili bir faktör bulunmaktadır.[2] Erkeklere bağlı faktörler arasında, vakaların yaklaşık %10'unda non-obstrüktif azoospermi (NOA) mevcuttur.NOA, hem hastalar için en yaygın, hem de doktorlar için en zorlayıcı azoospermi şeklidir, çünkü bu durumda spermatogenezin "geri dönüşümsüz" olduğuna ABSTRACT Spermatogenesis is a dynamic process which is managed with various hormonal and paracrine factors.Spermatogenesis is a stepwise process guided by autocrine, paracrine and endocrine factors and is under the influence of gonadotropins.The spermiogenesis, in which the motil spermatozoa occur, is the final step of spermatogenesis.In this step, the cell-skeleton structure, in which the Sertoli cells are important regulators, is fundamental.Sertoli cells provide a supportive environment for the development of germ cells and have a dynamic cytoskeleton.Gonadotropins, testosterone, estrogen and growth hormone have important roles in spermatogenesis and considerable defects may be considered in the absence of these.Infertility is a common problem that causes significant psychosocial challenges in couples.Azoospermia is responsible for approximately 10% of the male factor and the success of hormonal therapy is limited in this case.The targeted result with these treatments is to transform immature germ cells into mature cells capable of fertilizing oocytes.In this context, the mechanisms of action of gonadotropins and the clarification of the interaction between Leydig-Sertoli cells and germ cells are critical.With the better understanding of local and systemic factors involved in the spermatogenesis steps and by revealing genetic-based differences, new horizons may be opened in infertility treatment by transforming immature germ cells into mature cells.