Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury
Makaleler > Tam Makale · 2004
Yazarlar: A Bakshi, O Fisher, Taner DAĞCI, BT Himes, I Fischer, A Lowman
JOURNAL OF NEUROSURGERY-SPINE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 1, ss 322-329
DOI: 10.3171/spi.2004.1.3.0322
Özet
Object. Spinal cord injury (SCI) is a complex pathological entity, the treatment of which requires a multipronged approach. One way to integrate different therapeutic strategies for SCI is to develop implantable scaffolds that can deliver therapies in a synergistic manner. Many investigators have developed implantable "bridges," but an important property of such scaffolds-that is, mechanical compatibility with host tissues-has been neglected. In this study, the authors evaluated the results of implanting a mechanically matched hydrogel-based scaffold to treat SCI.