A transcranial magnetic stimulation study for the characterization of corticospinal pathway plasticity in children with neurological disorders
Makaleler > Tam Makale · 2022
Yazarlar: Hasan Tekgul, Ulas Saz, Muzaffer Polat, Timur KÖSE, Nurdan Tekgul, Omer Kitis
JOURNAL OF CLINICAL NEUROSCIENCE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2022, cilt 96, ss 1-7
DOI: 10.1016/j.jocn.2021.12.010
Özet
We aimed to investigate cortical and radicular TMS-evoked motor evoked potentials (MEPs) in children with neurological disorders (n = 57, mean age: 5.45 years) and agematched healthy controls (n = 46). Four TMS parameters were analyzed: MEP amplitudes, the latencies of MEP, the latency jump (cortical MEP latency at rest - cortical active-MEP latency at with slightly contracted targeted muscle), and central motor conduction time. Children with neurological disorders were categorized according to the two major types of neuronal plasticity; excessive plasticity: 29 children with cerebral palsy and impaired plasticity: 28 children with neurodegenerative diseases, stroke, and central nervous system infections. The active-MEP abnormalities (absent and prolonged latencies) were correlated with the location of cortical involvement on MRI patterns. We obtained a significantly increased rate of abnormal cortical activeMEPs in children with impaired plasticity (21/28, 75%) compared with excessive plasticity (18/29, 62%). The rate of absent MEP response is three times more in children with impaired plasticity (43%) than in children with excessive plasticity (14%). A more reduced latency jump was measured in children with impaired plasticity compared to children with excessive plasticity. TMS-evoked active-MEPs and latency jumping are valuable parameters for characterizing neuronal plasticity in children with neurological disorders. (c) 2021 Published by Elsevier Ltd.