Do patients infected with human coronavirus before the COVID-19 pandemic have less risk of being infected with COVID-19?
Makaleler > Tam Makale · 2024
Yazarlar: GAMZE ŞANLIDAĞ İŞBİLEN, Ayça AYDIN UYSAL, SELİN YİĞİT, ÖZGÜR APPAK, HİLAL SİPAHİ, GÜLENDAM BOZDAYI, ARZU SAYINER, Candan ÇİÇEK, ÖZLEM GÜZEL TUNÇCAN, OĞUZ REŞAT SİPAHİ
Turkish Journal of Medical Sciences, Uluslararası, Wos, 2024, cilt 54, ss 761-765
Özet
Background/aim: Although seasonal human coronaviruses (HCoVs) have long been recognized as respiratory tract viruses, the newly identified SARS-CoV-2 caused a pandemic associated with severe respiratory failure. We aimed to evaluate the incidence of COVID-19 infection in patients diagnosed in three tertiary teaching hospitals, both with and without prior confirmed HCoV infection, and to compare these cohorts in terms of COVID-19 contraction. Materials and methods: In our study, we examined HCoV PCR-positive cases obtained retrospectively between January 2014 and March 2020 from three University Hospital Microbiology Laboratories (Cohort 1), as well as PCR-negative patients detected in the same PCR cycle as the positive cases (Cohort 2). We also evaluated subgroups of HCoV-positive cases. Results: There was no difference in COVID-19 contraction rates between Cohort 1 and Cohort 2 (p = 0.724). When previous HCoV subgroups of COVID-19-positive patients were examined, no significant difference was found between the betacoronavirus and alphacoronavirus subgroups (p = 0.822), among the four groups (NL63, 229E, OC43, HKU-1) (p = 0.207), or between the OC43 subgroup and the other groups (p = 0.295). Conclusion: Being previously infected with HCoV did not provide protection against COVID-19 in our study group. We suggest evaluating the possible effect of previous OC43 infection on COVID-19 contraction in larger cohorts.