Massive Carbamazepine Overdose: Any Role of Hemodialysis?: Case Report
Articles > Article · 2011
Authors: Murat ÖZSARAÇ, Mustafa SEVER, Sema Gokova, Murat ERSEL, Meltem SEZİŞ
TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, Journal Indexed in SCI Expanded, International, 2011, vol 31, pp 702-705
DOI: 10.5336/medsci.2009-13386
Summary
Massive carbamazepine (CBZ) overdose is associated with life-threatening hemodynamic complications that present challenges for clinicians. We describe the highest-reported dose of CBZ intoxication in a patient who survived and discuss early hemodialysis option in a CBZ-poisoned patient. Although hemodialysis is reported to increase the elimination of CBZ despite its partiall effectiveness due to the poor water-solubility of CBZ, massive CBZ overdose can induce an acute renal failure and renal function should be monitored closely, and the data obtained from this case that standard low-flux HD might be used and is effective in the management of acute CBZ overdose in patients with associated electrolyte disorders and acute renal failure.