Phytochemical and Biological Investigations on Cephalaria anatolica
Articles > Article · 2017
Authors: Gaye SUMER, Nazlı SARIKAHYA, SÜHEYLA KIRMIZIGÜL
Records of Natural Products, Journal Indexed in SCI Expanded, International, WoS, 2017, vol 11, pp 497-507
DOI: 10.25135/rnp.64.17.03.056
Summary
The aerial parts of Cephalaria anatolica yielded two previously undescribed hederagenin-type triterpene glycosides, namely cephosides B (1) and C (2), in addition to eleven known natural compounds. The new compounds were identified as 3 The two new triterpenoid saponins and the n-butanol extract were evaluated for their hemolytic activity in human erythrocyte cells and immunomodulatory properties in activated whole blood cells by PMA plus ionomycin. While only n-butanol extract increased IL-1 concentration strongly with a value of 760.52 pg/mL, cephoside C and n-butanol extract augmented a slight IFN- secretion with values of 4874.11 and 4750.20 pg/mL, respectively. None of the compounds changed IL-2 levels significantly and showed hemolytic activity.