Wound healing effects of methanol extract ofLaurocerasus officinalisroem
Makaleler > Tam Makale · 2018
Yazarlar: S. Ayla, M. E. Okur, M. Y. Gunal, E. M. Ozdemir, D. Cicek Polat, Ayşegül YOLTAŞ, O. Biceroglu, S. Karahuseyinoglu
Biotechnic & Histochemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2018, cilt 94, ss 180-188
DOI: 10.1080/10520295.2018.1539242
Özet
Laurocerasus officinalis Roem. (syn: Prunus laurocerasus L.) is a member of Rosaceae family. We investigated the antimicrobial and antioxidant activity of L. officinalis Roem in wound healing both in vivo and in vitro using an excisional wound model model in mice. We used four groups of eight mice as follows: untreated (control), empty gel, extract + gel (L. officinalis + gel), and Madecassol® groups. All treatments were applied topically once daily. The scar area, percentage wound closure and epithelization time were measured. L. officinalis promoted wound healing and increased granulation tissue, epidermal regeneration and angiogenesis. L. officinalis extract, which is known for its antioxidant and antimicrobial activities, may be useful for promoting wound healing.