Disappearance of a GH Secreting Macroadenoma, during Long-term Somatostatin Analogue Administration
Articles > Article · 2009
Authors: MUSTAFA OZBEK, Mehmet ERDOĞAN, ERDEM AKBAL, GÜLSÜM GÖNÜLALAN
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, Journal Indexed in SCI Expanded, International, 2009, vol 117, pp 309-311
Summary
Acromegaly is caused by excessive growth hormone secretion, usually from a pituitary adenoma. Increased mortality rate is reverted to that of the normal Population after decreasing GH and IGF-1 levels to less than 2-2.5 mu g/liter and normal sex- and age-matched controls, respectively, regardless of the treatment employed. The use of somatostatin analogues as primary or adjunctive therapy has been widely applied in the management of acromegaly. A few cases have been reported in the literature, complete shrinkage of a pituitary GH secreting macroadenoma after long-term somatostatin analogue administration. We report a patient in whom long term (60 months) octreotide-L.A.R administration resulted in complete disappearance of a growth hormone secreting pituitary macroadenoma.