1H-benzimidazole derivatives as butyrylcholinesterase inhibitors: synthesis and molecular modeling studies
Makaleler > Tam Makale · 2016
Yazarlar: Güneş ÇOBAN, Luca CARLINO, AYŞE HANDE TARIKOGULLARI, Sülünay PARLAR ÇOŞKUN, GÖRKEM Sarikaya, Vildan ALPTÜZÜN, Ayse Selcen ALPAN, Hasan Semih GUNES, Ercin ERCIYAS
Medicinal Chemistry Research, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2016, cilt 25, ss 2005-2014
DOI: 10.1007/s00044-016-1648-1
Özet
A series of N-{2-[2-(1H-benzimidazole-2-yl)phenoxy]ethyl} substituted amine derivatives were synthesized and tested for their cholinesterase inhibitor activity. Acetylcholinesterase and butyrylcholinesterase inhibitor activities were evaluated in vitro by using Ellman's method. According to the activity results, all of the compounds displayed moderate acetylcholinesterase inhibitory activity and most of the compounds displayed remarkable butyrylcholinesterase inhibitory activity. Compound 3d was the most active compound in the series and also a selective butyrylcholinesterase inhibitor. Molecular docking studies and molecular dynamic simulations were also carried out.