Regulation of Epigenetic Modifiers Including KDM6B, by Interferon-gamma and Interleukin-4 in Human Macrophages
Articles > Article · 2017
Authors: Gökçe YILDIRIM BUHARALIOĞLU, Mark Bond, Graciela B. Sala-Newby, Charles C. T. Hindmarch, Andrew C. Newby
FRONTIERS IN IMMUNOLOGY, Journal Indexed in SCI Expanded, International, 2017, vol 8
Summary
Background: Interferon-gamma (IFN-gamma) or interleukin-4 (IL-4) drives widely different transcriptional programs in macrophages. However, how IFN-gamma and IL-4 alter expression of histone-modifying enzymes involved in epigenetic regulation and how this affects the resulting phenotypic polarization is incompletely understood.