Levels of leukotriene B-4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A
Articles > Article · 2000
Authors: Gülnur EMİNGİL, I Coker, FATMA GÜL ATİLLA, Afig BERDELİ
JOURNAL OF PERIODONTOLOGY, Journal Indexed in SCI Expanded, International, 2000, vol 71, pp 50-57
Summary
Background: Cyclosporine A (CsA) is a potent immunosuppressant effectively used to prevent organ transplant rejection and also to treat several systemic diseases. CsA-induced gingival overgrowth (CsA GO) is the most widely seen side effect of this drug; its pathogenesis is not completely understood. The aim of the present study was to identify the role of leukotriene B-4 (LTB4) and platelet activating factor (PAF) in the pathogenesis of CsA GO.