The synthesis and anticonvulsant activity of some omega-phthalimido-N-phenylacetamide and propionamide derivatives
Makaleler > Tam Makale · 2004
Yazarlar: Zeynep SOYER, FATMA SULTAN KILIÇ, KEVSER EROL, Mehmet Varol PABUÇÇUOĞLU
ARCHIV DER PHARMAZIE, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2004, cilt 337, ss 105-111
Özet
In this study, by combining anilide and N',N'-phthaloylglycinamide pharmacophores which are known to produce potent anticonvulsant compounds, sixteen omega-phthalimido-N-phenylacetamide and propionamide derivatives bearing substituents at positions 2 or 2,6 on N-phenyl ring have been synthesized. The structural confirmation of the title compounds was achieved by interpretation of spectral and analytical data. The anticonvulsant activity of the title compounds was determined against maximal electroshock seizure at 100 mg/kg dose level in mice. The preliminary screening results indicated that omega-phthalimido-N-phenylacetamide and propionamide nuclei have pronounced anticonvulsant activity against maximal electroshock seizure.